HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Aminopropylphosphonic acid → (3-{[3-(4-Ethylphenyl)-[2,4']-bipyridin-6-ylmethyl]-amino}-propyl)-phosphonic Acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Aminopropylphosphonic acid | HCID 97587 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | 3-(4-Ethylphenyl)-[2,4']-bipyridinyl-6-carbaldehyde | HCID 86619073 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | (3-{[3-(4-Ethylphenyl)-[2,4']-bipyridin-6-ylmethyl]-amino}-propyl)-phosphonic Acid | HCID 44217417 | — |
Reaktionsschritte
Following General Procedure M, 3-(4-ethyl-phenyl)-[2,4′]-bipyridinyl-6-carbaldehyde (Compound 58, 50 mg, 0.17 mmol), (3-amino-propyl)-phosphonic acid (24 mg, 0.17 mmol), Bu4NOH (0.17 ml, 0.17 mmol, 1 M in MeOH) and NaCNBH3 (11 mg, 0.17 mmol) in MeOH (3 ml) were reacted to produce the title compound as a white solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07728014B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-c102a456f8734650b93e4a7c443cdb74 |
| Quellennotiz | uspto-grants-2010_06 |