Hydrochloric Acid → HCID 85826896, Verbindung

Temperatur

0 °C

Methanol (2.81 g) and methyl acetate (30 ml) were added to octanenitrile (10.00 g), and the mixture was cooled to 0° C. Hydrogen chloride (7.50 g) was added and the mixture was stirred for 25 hours at the same temperature. Methylcyclohexane (60 ml) was added to the reaction solution, and then the solvent was distilled off under reduced pressure. Methylcyclohexane (20 ml) was added to the residue, the mixture was stirred for 1.5 hours at room temperature, and then crystals were filtered. The crystals were washed with methylcyclohexane and dried under reduced pressure to give the title compound as a white solid (14.45 g, 93.4% yield).

1. distillationthe solvent was distilled off under reduced pressure
2. additionMethylcyclohexane (20 ml) was added to the residue
3. stirringthe mixture was stirred for 1.5 hours at room temperature
4. filtrationcrystals were filtered
5. washThe crystals were washed with methylcyclohexane
6. customdried under reduced pressure

ORD-Eintrag

ord-ea6a390f11f543fbae7d591a621f148f

Quelldatensatz

uspto-grants-2013_06

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08455659B2