Hydrochloric Acid → (R)-(4-fluoro-phenylamino)-phenyl-acetic acid

HRID 1255085Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1255085
C[O:2][C:3](=[O:19])[C@H:4]([NH:11][C:12]1[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.Cl>O1CCOCC1>[F:18][C:15]1[CH:16]=[CH:17][C:12]([NH:11][C@H:4]([C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:3]([OH:19])=[O:2])=[CH:13][CH:14]=1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 59401123(R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester

Produkt 1

HCID 7006576(R)-(4-fluoro-phenylamino)-phenyl-acetic acidAusbeute 87 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester (I252) (510 mg, 1.97 mmol) in dioxane (10 mL), is added 12N HCl (10 mL) and the mixture is heated at 70° C. for 12 hours. The organic solvent is evaporated, the mixture is cooled to 0° C. and the resulting solid is collected by filtration to obtain intermediate I255 as a brownish solid (420 mg, 87% yield).

Aufarbeitung

  1. customThe organic solvent is evaporated
  2. temperaturethe mixture is cooled to 0° C.
  3. filtrationthe resulting solid is collected by filtration
  4. customto obtain intermediate

Quellen und Nachweise

ORD-Eintrag
ord-4c03bbae27894013bbe836af538ca61c
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08455646B2

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