5-(Carboxymethyl)-2-chlorobenzoic acid → 2-Chloro-5-(2-hydroxyethyl)benzaldehyde

Beteiligte Stoffe

Reaktionsschritte

Manganese (IV) dioxide (1.00 g) was added to a solution of 2-(4-chloro-3-(hydroxymethyl)phenyl)ethanol [Aromatic Intermediate 7, step c] (0.200 g) in DCM (5 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then filtered through Celite, washing the residue well with DCM. The filtrate and washings were concentrated in vacuo to afford the subtitled compound as a colourless oil. Yield 0.197 g.

Herkunft & Nachweise