Sulfuric Acid → HCID 178501284, Verbindung

HRID 1255461Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1255461
[OH:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]1.S(=O)(=O)(O)O.[C:16](=O)([O-])[O-].[Na+].[Na+]>CO>[CH3:16][O:9][C:8]([C@H:5]1[CH2:6][CH2:7][C@@H:2]([OH:1])[CH2:3][CH2:4]1)=[O:10]

Komponenten

5

Edukt 3

HCID 1118Sulfuric AcidHCID 10340Sodium CarbonateHCID 178525779HCID 178525779, Verbindung

Produkt 1

HCID 178501284HCID 178501284, VerbindungAusbeute 94 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of cis-4-hydroxy-cyclohexanecarboxylic acid (10.0 g, 69.4 mmol) and a catalytic amount of concentrated sulfuric acid in methanol (700 ml) was heated at reflux over night. After cooling to room temperature the reaction mixture was neutralized by the addition of solid sodium carbonate. The mixture was stirred for 30 min, filtered and concentrated in vacuo. The residue was triturated in ethyl acetate (150 ml). The solids were removed by filtration. The filtrate was concentrated in vacuo to give the crude product (10.3 g, 94%) as colorless oil, which was used in the following steps without further purification. MS m/e: 159 (M+H+).

Aufarbeitung

  1. temperatureat reflux over night
  2. filtrationfiltered
  3. concentrationconcentrated in vacuo
  4. customThe residue was triturated in ethyl acetate (150 ml)
  5. customThe solids were removed by filtration
  6. concentrationThe filtrate was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-2b01c02edcf84a68ba820588d4fdb571
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461152B2

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