[Cl:1][C:2]1[CH:9]=[C:8](F)[CH:7]=[CH:6][C:3]=1C#N.[Br:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][C:13]=1[CH:19]1[O:23][CH2:22][CH2:21][O:20]1.C(=O)([O-])[O-].[K+].[K+].C(OCC)(=O)C.O.C[N:38]([CH3:41])C=O>>[Br:11][C:12]1[CH:17]=[CH:16][C:15]([O:18][C:3]2[CH:6]=[CH:7][C:8]([C:41]#[N:38])=[CH:9][C:2]=2[Cl:1])=[CH:14][C:13]=1[CH:19]1[O:20][CH2:21][CH2:22][O:23]1A mixture of 2-chloro-4-fluorobenzonitrile (4.43 g, 28.4 mmol), 4-bromo-3-(1,3-dioxolan-2-yl)phenol (6.96 g, 28.4 mmol), and potassium carbonate (4.70 g, 34.1 mmol) in N,N-dimethylformamide (60 mL) was stirred at 100° C. under nitrogen atmosphere overnight. The mixture was poured into ethyl acetate/water. The organic layer was washed with brine and dried on anhydrous sodium sulfate. The solvent was removed under reduced pressure to give crude 4-(4-bromo-3-(1,3-dioxolan-2-yl)phenoxy)-3-chlorobenzonitrile (10.8 g), which was used for the next step without purification.
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