1,4-Dioxane → Methyl 4-(6-pyridin-3-ylpyrazolo[1,5-c]pyrimidin-3-yl)thiophene-2-carboxylate

HRID 1255859Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1255859
CC1(C)C(C)(C)OB([C:9]2[CH:10]=[C:11]([C:14]([O:16][CH3:17])=[O:15])[S:12][CH:13]=2)O1.Br[C:20]1[CH:21]=[N:22][N:23]2[CH:28]=[C:27](C3C=NC=CC=3)[CH:26]=[N:25][C:24]=12.C(=O)(O)[O-].[Na+].O1[CH2:45][CH2:44]OCC1>>[N:22]1[CH:45]=[CH:44][CH:24]=[C:20]([N:25]2[CH:26]=[CH:27][C:28]3=[C:20]([C:9]4[CH:10]=[C:11]([C:14]([O:16][CH3:17])=[O:15])[S:12][CH:13]=4)[CH:21]=[N:22][N:23]3[CH2:24]2)[CH:21]=1

Komponenten

5

Edukt 4

HCID 312751,4-DioxaneHCID 516892Sodium BicarbonateHCID 52911233Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylateHCID 687770603-Bromo-6-pyridin-3-ylpyrazolo[1,5-a]pyrimidine

Produkt 1

HCID 68775345Methyl 4-(6-pyridin-3-ylpyrazolo[1,5-c]pyrimidin-3-yl)thiophene-2-carboxylate

Reaktionsbedingungen

Temperatur
85 °C

Versuchsvorschrift

A solution of methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate (1.09 g, 4.1 mmol) and 3-bromo-6-pyridin-3-ylpyrazolo[1,5-a]pyrimidine (1.1 g, 4.1 mmol) in dioxane (20 mL) and 1M aqueous sodium bicarbonate (12.2 mL, 12.2 mmol) was degassed with nitrogen and treated with palladium tetrakistriphenylphosphine (0.24 g, 0.20 mmol) and heated to 85° C. for 16 hours. The reaction was cooled to room temperature and partitioned between water/methylene chloride. The organics were washed with water and brine, dried over sodium sulfate, filtered and evaporated in vacuo. Purification by flash chromatography (1-5% methanol/methylene chloride) gave methyl 4-(6-pyridin-3-ylpyrazolo[1,5-c]pyrimidin-3-yl)thiophene-2-carboxylate. LC-MS SIMS: m/z 337.1 [M+H]+.

Aufarbeitung

  1. temperatureThe reaction was cooled to room temperature
  2. custompartitioned between water/methylene chloride
  3. washThe organics were washed with water and brine
  4. dry with materialdried over sodium sulfate
  5. filtrationfiltered
  6. customevaporated in vacuo
  7. customPurification by flash chromatography (1-5% methanol/methylene chloride)

Quellen und Nachweise

ORD-Eintrag
ord-05c14e3c721f47ba83f5e5b536ae1fe4
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461162B2

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