2,6-Dichloro-4-(trifluoromethyl)pyridine → 2-Chloro-6-methoxy-4-(trifluoromethyl)pyridine

HRID 1255901

Reaktionsgleichung

Reaktionsgleichung von HRID 1255901
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4](Cl)[N:3]=1.[OH-:13].[Na+].[CH3:15]O>CO>[CH3:15][O:13][C:4]1[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=[C:2]([Cl:1])[N:3]=1

Komponenten

4

Edukt 2

HCID 5209682,6-Dichloro-4-(trifluoromethyl)pyridineHCID 23721981Sodium hydroxide methanol

Produkt 1

HCID 568323142-Chloro-6-methoxy-4-(trifluoromethyl)pyridineAusbeute 99,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

To a solution of 2,6-dichloro-4-trifluoromethylpyridine (10 g, 46.3 mmol) in methanol (200 mL) was added 25% NaOH/MeOH (12.5 g, 13.2 mL, 231 mmol), which was then stirred at 50° C. for 2 h and then at room temperature overnight. The reaction mixture was extracted with pentane, and the extract was concentrated in vacuo to afford 2-methoxy-6-chloro-4-trifluoromethylpyridine (9.79 g), used without further purification.

Aufarbeitung

  1. customat room temperature
  2. customovernight
  3. extractionThe reaction mixture was extracted with pentane
  4. concentrationthe extract was concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-25a597e95e3b4c1cb661ff371d90f7d5
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461164B2

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