2-{2-[2-(2-[4-(4,5-Dichloro-2-fluoro-phenylamino)-6-nitro-quinazoline-7-yloxy]-ethoxy]-ethoxy}-ethoxy)-ethanol → n4-(4,5-Dichloro-2-fluoro-phenyl)-(2-{2-[2-(2-ethoxy)-ethoxy]-ethoxy}-ethoxy)-quinazoline-4,6-diamine
Reaktionsgleichung
[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16](OCCOCC)=[C:17]([NH2:20])[CH:18]=3)[N:13]=[CH:12][N:11]=2)=[C:4]([F:27])[CH:3]=1.ClC1C(Cl)=CC(NC2C3C(=[CH:42][C:43]([O:50][CH2:51][CH2:52][O:53][CH2:54][CH2:55][O:56][CH2:57][CH2:58][O:59]CCO)=C([N+]([O-])=O)C=3)N=CN=2)=C(F)C=1>>[Cl:1][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([NH2:20])[CH:18]=3)[N:13]=[C:12]([O:59][CH2:58][CH2:57][O:56][CH2:55][CH2:54][O:53][CH2:52][CH2:51][O:50][CH2:43][CH3:42])[N:11]=2)=[C:4]([F:27])[CH:3]=1Komponenten
3
Edukt 2
Produkt 1
Versuchsvorschrift
Compound 41b is prepared as described hereinabove for Compound 41a, using Compound 29b a starting material.