Pyridine → HCID 67174065, Verbindung

HRID 1256103Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1256103
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:9][O:8][B:7]([OH:10])[C:6]=2[CH:11]=1.N1C=CC=CC=1.[C:18]([C:20]1[CH:25]=[C:24]([N+:26]([O-:28])=[O:27])[CH:23]=[CH:22][C:21]=1[S:29](Cl)(=[O:31])=[O:30])#[N:19]>CC#N.CN(C=O)C>[C:18]([C:20]1[CH:25]=[C:24]([N+:26]([O-:28])=[O:27])[CH:23]=[CH:22][C:21]=1[S:29]([NH:1][C:2]1[CH:3]=[CH:4][C:5]2[CH2:9][O:8][B:7]([OH:10])[C:6]=2[CH:11]=1)(=[O:31])=[O:30])#[N:19]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 37701876-Aminobenzo(c)(1,2)oxaborol-1(3H)-olHCID 433636332-Cyano-4-nitrobenzene-1-sulfonyl chloride

Produkt 1

HCID 67174065HCID 67174065, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21891449acetonitrile N,N-dimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 6-aminobenzo[c][1,2]oxaborol-1(3H)-ol (16.4 g, 0.11 mol) and pyridine (10.3 g, 0.13 mol) in MeCN/DMF (400 mL/100 mL) was added 2-cyano-4-nitrobenzene-1-sulfonyl chloride (24.7 g, 0.1 mol) at 0° C., then the solution was stirred at room temperature overnight. The mixture was concentrated in vacuo, and DCM and water was added to the residue. The organic layer was dried over Na2SO4 and concentrated to give the crude product.

Aufarbeitung

  1. concentrationThe mixture was concentrated in vacuo, and DCM and water
  2. additionwas added to the residue
  3. dry with materialThe organic layer was dried over Na2SO4
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-b229b69169d447adbfe0c0a4665dfc64
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461134B2

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