Pyridine → 1-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one O-Methyloxime

HRID 12563

Reaktionsgleichung

Reaktionsgleichung von HRID 12563
[C:1]1([C:7]2[N:12]=[C:11]([C:13](=O)[CH2:14][CH3:15])[CH:10]=[CH:9][C:8]=2[C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:26])([F:25])[F:24])=[CH:19][CH:18]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:27][O:28][CH3:29].Cl.N1C=CC=CC=1>CCO>[CH3:29][O:28][N:27]=[C:13]([C:11]1[CH:10]=[CH:9][C:8]([C:17]2[CH:22]=[CH:21][C:20]([C:23]([F:24])([F:25])[F:26])=[CH:19][CH:18]=2)=[C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:12]=1)[CH2:14][CH3:15]

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 593388331-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one2×

Produkt 1

HCID 722584701-[6-Phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one O-Methyloxime

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Following General Procedure P, 1-[6-phenyl-5-(4-trifluoromethyl-phenyl)-pyridin-2-yl]-propan-1-one (Compound 78), (24 mg, 0.07 mmol), NH2OMe—HCl (23 mg, 0.25 mmol) and pyridine (21 mg, 0.28 mmol) in EtOH (2 ml) were reacted to give title compound as a white solid.

Aufarbeitung

  1. customwere reacted

Quellen und Nachweise

ORD-Eintrag
ord-28bcb12bc8624d6c93962d8249bed849
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728014B2

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