(5-Methylthiophen-2-yl)boronic acid → 7-(5-Methylthiophen-2-yl)pyrazolo[1,5-a]pyrimidin-5-amine

HRID 1256306Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1256306
Cl[C:2]1[N:7]2[N:8]=[CH:9][CH:10]=[C:6]2[N:5]=[C:4]([NH2:11])[CH:3]=1.[CH3:12][C:13]1[S:17][C:16](B(O)O)=[CH:15][CH:14]=1>>[CH3:12][C:13]1[S:17][C:16]([C:2]2[N:7]3[N:8]=[CH:9][CH:10]=[C:6]3[N:5]=[C:4]([NH2:11])[CH:3]=2)=[CH:15][CH:14]=1

Komponenten

3

Edukt 2

HCID 2734374(5-Methylthiophen-2-yl)boronic acidHCID 442513067-Chloropyrazolo[1,5-a]pyrimidin-5-amine

Produkt 1

HCID 582071337-(5-Methylthiophen-2-yl)pyrazolo[1,5-a]pyrimidin-5-amine

Versuchsvorschrift

The titled compound was prepared using a procedure analogous to that described in connection with Example 15 except that 7-chloropyrazolo[1,5-a]pyrimidin-5-amine (1E) and 5-methylthiophen-2-ylboronic acid were used as starting materials. 1H NMR (400 MHz, CHLOROFORM-d) δ 2.59 (s, 3H), 4.76 (s, 2H), 6.21 (d, J=1.8 Hz, 1H), 6.44 (s, 1H), 6.89 (d, J=3.5 Hz, 1H), 7.99-8.04 (m, 2H).

Quellen und Nachweise

ORD-Eintrag
ord-22fe7a462d134289bbbb64ce94931d7d
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461163B2

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