Hydrochloric Acid → 3-[(Pyrrolidin-1-yl)methyl]benzoic acid hydrochloride

HRID 1256632

Reaktionsgleichung

Reaktionsgleichung von HRID 1256632
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:5]=1.[ClH:17]>>[ClH:17].[N:11]1([CH2:10][C:6]2[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=2)[C:3]([OH:16])=[O:2])[CH2:15][CH2:14][CH2:13][CH2:12]1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 53429637Methyl 3-(pyrrolidin-1-ylmethyl)benzoate

Produkt 1

HCID 185258743-[(Pyrrolidin-1-yl)methyl]benzoic acid hydrochloride

Versuchsvorschrift

A solution of 3-pyrrolidin-1-ylmethyl-benzoic acid methyl ester (800 mg, 3.6 mmol) in aqueous 25% hydrochloric acid (15 mL) was stirred at 90° C. for 4 hours. The solvent was evaporated affording the title compound as brown oil (quantitative) that was used as such for the next step.

Aufarbeitung

  1. customThe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-13aa797902c049a9a0a2029f555dbccb
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461193B2

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