Thionyl Chloride → HCID 86659460, Verbindung

HRID 1256633

Reaktionsgleichung

Reaktionsgleichung von HRID 1256633
[ClH:1].[N:2]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=2)[C:11](O)=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3]1.S(Cl)([Cl:19])=O>O1CCCC1>[ClH:19].[N:2]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][CH:16]=2)[C:11]([Cl:1])=[O:12])[CH2:6][CH2:5][CH2:4][CH2:3]1

Komponenten

4

Edukt 2

HCID 24386Thionyl ChlorideHCID 185258743-[(Pyrrolidin-1-yl)methyl]benzoic acid hydrochloride

Produkt 1

HCID 86659460HCID 86659460, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A suspension of 3-pyrrolidin-1-ylmethyl-benzoic acid hydrochloride (850 mg, 3.5 mmol) in dry tetrahydrofuran was treated with 2.55 mL of thionyl chloride (35 mmol, 10 eq) and stirred at room temperature for 2 hours. The solution thus obtained was then evaporated to dryness, the residue suspended in dry toluene, evaporated to dryness and dried under vacuum affording the title compound as pale brown solid (quantitative).

Aufarbeitung

  1. customThe solution thus obtained
  2. customwas then evaporated to dryness
  3. customevaporated to dryness
  4. customdried under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f80cf0c6d3fd4e84802ff117c8cf085f
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461193B2

Verknüpfte Notizen

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