Thionyl Chloride → 3-Pyrrolidin-1-ylmethyl-benzoyl chloride hydrochloride

Beteiligte Stoffe

Reaktionsschritte

A suspension of 3-pyrrolidin-1-ylmethyl-benzoic acid hydrochloride (850 mg, 3.5 mmol) in dry tetrahydrofuran was treated with 2.55 mL of thionyl chloride (35 mmol, 10 eq) and stirred at room temperature for 2 hours. The solution thus obtained was then evaporated to dryness, the residue suspended in dry toluene, evaporated to dryness and dried under vacuum affording the title compound as pale brown solid (quantitative).

Herkunft & Nachweise