Trifluoroacetic acid → HCID 178495632, Verbindung
Reaktionsgleichung
C(OC(=O)[NH:7][C@H:8]1[CH2:13][CH2:12][C@H:11]([CH2:14][O:15][CH3:16])[CH2:10][CH2:9]1)(C)(C)C.[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21]>C(Cl)Cl>[F:18][C:19]([F:24])([F:23])[C:20]([OH:22])=[O:21].[CH3:16][O:15][CH2:14][C@H:11]1[CH2:12][CH2:13][C@H:8]([NH2:7])[CH2:9][CH2:10]1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
A solution of trans (4-methoxymethyl-cyclohexyl)-carbamic acid tert-butyl ester (1.41 g, 5.80 mmol) in DCM (12 mL) was treated with trifluoroacetic acid (4 mL). The mixture was stirred for 1 hour then concentrated under vacuum. The residue was taken into ether and concentrated under vacuum a total of five times to afford 1.88 g of crude trans 4-methoxymethyl-cyclohexylamine trifluoroacetic acid salt as a colourless residue. This was not purified further. 1H NMR (400 MHz, CDCl3): δ 7.48 (br s, 3H), 3.34 (s, 3H), 3.22 (d, 2H), 3.15-3.00 (m, 1H), 2.11-2.00 (m, 2H), 1.94-1.83 (m, 2H), 1.65-1.50 (m, 1H), 1.46-1.31 (m, 2H), 1.13-0.96 (m, 2H).