Ammonia → 6-(4-Fluorophenyl)-1,2,4-triazin-3-amine

HRID 1257766Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1257766
[NH3:1].Cl[C:3]1[N:4]=[N:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)=[CH:7][N:8]=1>O1CCCC1>[F:15][C:12]1[CH:13]=[CH:14][C:9]([C:6]2[N:5]=[N:4][C:3]([NH2:1])=[N:8][CH:7]=2)=[CH:10][CH:11]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 213152193-Chloro-6-(4-fluorophenyl)-1,2,4-triazine

Produkt 1

HCID 672240676-(4-Fluorophenyl)-1,2,4-triazin-3-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
50 °C

Versuchsvorschrift

Ammonia gas was bubbled through a solution of 3-chloro-6-(4-fluorophenyl)-1,2,4-triazine (600 mg, 0.0029 mol) in tetrahydrofuran (8 mL) for 5 min at −40° C. The reaction mixture was sealed and heated at 50° C. for 2 hours. The mixture was concentrated under reduced pressure to yield the desired product (550 mg) which was directly used in the next step without further purification. LCMS: (M+H)=209.1.

Aufarbeitung

  1. customThe reaction mixture was sealed
  2. concentrationThe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-3e84599133614d318e53b295f484aaa6
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461330B2

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