Ammonia → 5-(4-Fluorophenyl)pyrimidin-2-amine

HRID 1257773Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1257773
Cl[C:2]1[N:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([F:14])=[CH:10][CH:9]=2)=[CH:4][N:3]=1.[NH3:15]>CO>[F:14][C:11]1[CH:12]=[CH:13][C:8]([C:5]2[CH:4]=[N:3][C:2]([NH2:15])=[N:7][CH:6]=2)=[CH:9][CH:10]=1

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 203333512-Chloro-5-(4-fluorophenyl)pyrimidine

Produkt 1

HCID 129466475-(4-Fluorophenyl)pyrimidin-2-amine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

2-Chloro-5-(4-fluorophenyl)pyrimidine (376 mg) in 7M of ammonia in methanol (10 mL) in a sealed tube was heated at 50° C. overnight. After concentration, the product was obtained (360 g) which was used in the next reaction step without further purification. LCMS: (M+H)=190.1.

Aufarbeitung

  1. concentrationAfter concentration
  2. customthe product was obtained (360 g) which
  3. customwas used in the next reaction step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-b4d8513ff7bd4af48b0a096b31c3c6f6
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461330B2

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