Trifluoroacetic acid → Trifluoroacetic acid

HRID 1257934Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1257934
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[C:8]([CH2:10][C:11]1([N:24]2[CH:28]=[C:27]([C:29]3[CH:30]=[N:31][C:32]4[N:33]([C:35]([CH2:38][C:39]5[CH:40]=[C:41]6[C:46](=[CH:47][CH:48]=5)[N:45]=[CH:44][CH:43]=[CH:42]6)=[CH:36][N:37]=4)[N:34]=3)[CH:26]=[N:25]2)[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]1)#[N:9]>C(Cl)Cl>[N:45]1[C:46]2[C:41](=[CH:40][C:39]([CH2:38][C:35]3[N:33]4[N:34]=[C:29]([C:27]5[CH:26]=[N:25][N:24]([C:11]6([CH2:10][C:8]#[N:9])[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]6)[CH:28]=5)[CH:30]=[N:31][C:32]4=[N:37][CH:36]=3)=[CH:48][CH:47]=2)[CH:42]=[CH:43][CH:44]=1.[C:3]([OH:5])([C:2]([F:7])([F:6])[F:1])=[O:4]

Komponenten

5

Edukt 2

HCID 6422Trifluoroacetic acidHCID 67223980tert-butyl 4-(cyanomethyl)-4-{4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-1H-pyrazol-1-yl}piperidine-1-carboxylate

Produkt 2

HCID 6422Trifluoroacetic acidHCID 67224951(4-{4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-1H-pyrazol-1-yl}piperidin-4-yl)acetonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Trifluoroacetic Acid (0.5 mL) was added to a solution of tert-butyl 4-(cyanomethyl)-4-{4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]-1H-pyrazol-1-yl}piperidine-1-carboxylate (0.015 g, 0.000027 mol) in methylene chloride (0.5 mL). The mixture was stirred at RT for 0.5 h. The volatiles were removed under reduced pressure to give the desired product as a TFA salt which was directly used in the next step without further purification. LCMS: (M+H)=450.5.

Aufarbeitung

  1. customThe volatiles were removed under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-f0bae2a45c914d669d91e3767c313fc2
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08461330B2

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