6-Amino-1-ethyl-3-propyl-2,4(1H,3H)-pyrimidinedione → 6-Amino-1-ethyl-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione

HRID 1258022Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1258022
[NH2:1][C:2]1[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[N:5]([CH2:11][CH2:12][CH3:13])[C:4](=[O:14])[CH:3]=1.[N:15]([O-])=[O:16].[Na+]>C(O)(=O)C.O>[NH2:1][C:2]1[N:7]([CH2:8][CH3:9])[C:6](=[O:10])[N:5]([CH2:11][CH2:12][CH3:13])[C:4](=[O:14])[C:3]=1[N:15]=[O:16]

Komponenten

4

Edukt 2

HCID 956756-Amino-1-ethyl-3-propyl-2,4(1H,3H)-pyrimidinedioneHCID 23668193Sodium Nitrite

Produkt 1

HCID 219163746-Amino-1-ethyl-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899381Acetic acid--water (1/1)Lösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 6-amino-1-ethyl-3-propyl-1,3-dihydropyrimidine-2,4-dione (1.4 g, 7.1 mmol) in a mixture of 50% acetic acid/water (35 ml) was added sodium nitrite (2 g, 28.4 mmol) in portions over a period of 10 minutes. The mixture was stirred at 70° C. for 1 hour, then the reaction mixture concentrated to a low volume under reduced pressure. The solid was filtered off, and washed with water, to provide 6-amino-1-ethyl-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (1).

Aufarbeitung

  1. concentrationthe reaction mixture concentrated to a low volume under reduced pressure
  2. filtrationThe solid was filtered off
  3. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-55d28a956f584c0a990141402a6f3e72
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466129B2

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