6-Amino-3-propylpyrimidine-2,4(1H,3H)-dione → 6-Amino-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione

HRID 1258025Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1258025
[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[CH:3]=1.[N:13]([O-])=[O:14].[Na+]>C(O)(=O)C.O>[NH2:1][C:2]1[NH:7][C:6](=[O:8])[N:5]([CH2:9][CH2:10][CH3:11])[C:4](=[O:12])[C:3]=1[N:13]=[O:14]

Komponenten

4

Edukt 2

HCID 110302506-Amino-3-propylpyrimidine-2,4(1H,3H)-dioneHCID 23668193Sodium Nitrite

Produkt 1

HCID 144253236-Amino-5-nitroso-3-propylpyrimidine-2,4(1H,3H)-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21899381Acetic acid--water (1/1)Lösungsmittel

Reaktionsbedingungen

Temperatur
70 °C

Versuchsvorschrift

To a solution of 6-amino-3-propyl-1,3-dihydropyrimidine-2,4-dione (5.6 g) in a mixture of 50% acetic acid/water (160 ml) at 70° C. was added sodium nitrite (4.5 g) in portions over a period of 15 minutes. The mixture was stirred at 70° C. for 45 minutes, then the reaction mixture concentrated to a low volume under reduced pressure. The solid was filtered off, and washed with water, to provide 6-amino-5-nitroso-3-propyl-1,3-dihydropyrimidine-2,4-dione, a compound of formula (11).

Aufarbeitung

  1. concentrationthe reaction mixture concentrated to a low volume under reduced pressure
  2. filtrationThe solid was filtered off
  3. washwashed with water

Quellen und Nachweise

ORD-Eintrag
ord-b0334e5408d3410ba9dceaf80f8f5249
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466129B2

Notizen zur Reaktion

Wird geladen…