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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 12585Erstellt: 24. Oktober 2026

Trifluoroacetic acid → (R)-2-Amino-4-(4-heptyloxy-phenyl)-2-methyl-butanoic acid

https://huagongshe.com/de/reaction/12585

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
EduktTrifluoroacetic acidHCID 6422—
Edukt(R)-2-tert-butoxycarbonylamino-4-(4-heptyloxy-phenyl)-2-methyl-butyric acidHCID 58897679—
LösungsmittelDichloromethaneHCID 6344—
Produkt(R)-2-Amino-4-(4-heptyloxy-phenyl)-2-methyl-butanoic acidHCID 11404040—

Reaktionsschritte

To a stirred solution of (R)-2-tert-butoxycarbonylamino-4-(4-heptyloxy-phenyl)-2-methyl-butyric acid (43 mg, 0.11 mMol) in CH2Cl2 (2 ml) is added trifluoroacetic acid (0.1 ml). The mixture is stirred at RT for 8 hours. After that time, the reaction mixture is concentrated under reduced pressure. Column chromatography eluting with 5%→25% MeOH in CH2Cl2 gives the title compound as a colourless oil.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS07728020B2
Quelldatensatzuspto-grants-2010_06
ORD IDord-dc96f4ef043c40f5b91e8bb96a45a857
Quellennotizuspto-grants-2010_06