HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Trifluoroacetic acid → (R)-2-Amino-4-(4-heptyloxy-phenyl)-2-methyl-butanoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Trifluoroacetic acid | HCID 6422 | — |
| Edukt | (R)-2-tert-butoxycarbonylamino-4-(4-heptyloxy-phenyl)-2-methyl-butyric acid | HCID 58897679 | — |
| Lösungsmittel | Dichloromethane | HCID 6344 | — |
| Produkt | (R)-2-Amino-4-(4-heptyloxy-phenyl)-2-methyl-butanoic acid | HCID 11404040 | — |
Reaktionsschritte
To a stirred solution of (R)-2-tert-butoxycarbonylamino-4-(4-heptyloxy-phenyl)-2-methyl-butyric acid (43 mg, 0.11 mMol) in CH2Cl2 (2 ml) is added trifluoroacetic acid (0.1 ml). The mixture is stirred at RT for 8 hours. After that time, the reaction mixture is concentrated under reduced pressure. Column chromatography eluting with 5%→25% MeOH in CH2Cl2 gives the title compound as a colourless oil.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07728020B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-dc96f4ef043c40f5b91e8bb96a45a857 |
| Quellennotiz | uspto-grants-2010_06 |