Hydrochloric Acid → 2,4-Dichloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzimidazol-2-ylamino]benzylamine

HRID 1258680Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1258680
Cl.C(OC(=O)[NH:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([Cl:16])=[C:12]([NH:17][C:18]2[N:22]([CH3:23])[C:21]3[CH:24]=[C:25]([N:29]4[CH2:34][CH2:33][CH2:32][CH:31]([C:35]([F:38])([F:37])[F:36])[CH2:30]4)[C:26]([Cl:28])=[CH:27][C:20]=3[N:19]=2)[C:11]=1[Cl:39])(C)(C)C>O1CCOCC1>[Cl:39][C:11]1[C:12]([NH:17][C:18]2[N:22]([CH3:23])[C:21]3[CH:24]=[C:25]([N:29]4[CH2:34][CH2:33][CH2:32][CH:31]([C:35]([F:38])([F:37])[F:36])[CH2:30]4)[C:26]([Cl:28])=[CH:27][C:20]=3[N:19]=2)=[C:13]([Cl:16])[CH:14]=[CH:15][C:10]=1[CH2:9][NH2:8]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 86674334N-{2,4-Dichloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzimidazol-2-ylamino]benzyl}-carbamic acid tert-butyl ester

Produkt 1

HCID 866743352,4-Dichloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzimidazol-2-ylamino]benzylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

4 M HCl in dioxane (38 mL) was added to N-{2,4-dichloro-3-[5-chloro-1-methyl-6-(3-(trifluoromethyl)piperidin-1-yl)-1H-benzimidazol-2-ylamino]benzyl}-carbamic acid tert-butyl ester (5.4 g, 8.9 mmol) in dioxane (300 mL) and stirred at rt overnight. The reaction mixture was concentrated and the resulting residue was diluted with aq. NaHCO3-solution. The aq. phase was extracted with EtOAc, the organic phase was dried with Na2SO4 and concentrated.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. additionthe resulting residue was diluted with aq. NaHCO3-solution
  3. extractionThe aq. phase was extracted with EtOAc
  4. dry with materialthe organic phase was dried with Na2SO4
  5. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-fd56f015cb654c11a4748a557d730aa6
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466186B2

Notizen zur Reaktion

Wird geladen…