Ammonia → 2-Amino-6-fluoro-3-nitrobenzonitrile

HRID 1258714Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1258714
[NH3:1].CCO.F[C:6]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][CH:11]=[C:10]([F:17])[C:7]=1[C:8]#[N:9]>C1COCC1>[NH2:1][C:6]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][CH:11]=[C:10]([F:17])[C:7]=1[C:8]#[N:9]

Komponenten

5

Edukt 3

HCID 222AmmoniaHCID 702EthanolHCID 27370302,6-Difluoro-3-nitrobenzonitrile

Produkt 1

HCID 679578082-Amino-6-fluoro-3-nitrobenzonitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

A solution of NH3 in EtOH (19 mL, 8.6 M, 160 mmol) was added dropwise to a solution of 2,6-difluoro-3-nitrobenzonitrile (10 g, 54 mmol) in THF (50 mL) at 0° C. under Ar and the resulting mixture was stirred at 0° C. for 1 h. The mixture was concentrated and the residue washed with brine and extracted with EtOAc. The organic layer was dried over Na2SO4, filtered and concentrated.

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. washthe residue washed with brine
  3. extractionextracted with EtOAc
  4. dry with materialThe organic layer was dried over Na2SO4
  5. filtrationfiltered
  6. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-1f7484e7ad5f442db873fb14fef8435f
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466186B2

Notizen zur Reaktion

Wird geladen…