1-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one → 1-(diphenylmethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one

HRID 1259555Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1259555
C1(CCN2C3C(=CC=CC=3)C(O)(C3C(O)=CC4OCOC=4C=3)C2=O)CC1.[C:27]1([CH:33]([C:55]2[CH:60]=[CH:59][CH:58]=[CH:57][CH:56]=2)[N:34]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[C:36](O)([C:43]3[C:51]([OH:52])=[CH:50][C:46]4[O:47][CH2:48][O:49][C:45]=4[CH:44]=3)[C:35]2=[O:54])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1>>[C:55]1([CH:33]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:34]2[C:42]3[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=3)[CH:36]([C:43]3[C:51]([OH:52])=[CH:50][C:46]4[O:47][CH2:48][O:49][C:45]=4[CH:44]=3)[C:35]2=[O:54])[CH:56]=[CH:57][CH:58]=[CH:59][CH:60]=1

Komponenten

3

Edukt 2

HCID 120042481-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-oneHCID 588725381-(2-cyclopropylethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one

Produkt 1

HCID 120042491-(diphenylmethyl)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one

Versuchsvorschrift

Following the procedure as described in PREPARATION 2C, and making the variations to replace 1-(2-cyclopropylethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one with 1-(diphenylmethyl)-3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one, the title compound was obtained (84%) as an off-white solid: MS (ES+) m/z 458.4 (M+23).

Quellen und Nachweise

ORD-Eintrag
ord-443e8307a01e4f8ebb1053678d7c5e54
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466188B2

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