HCID 12003986, Verbindung → 3-(3-(Benzo[d][1,3]dioxol-5-yl)-2-oxo-1-pentylindolin-3-yl)propanoic acid
Reaktionsgleichung
O1C2C=CC(C3(CC(OC)=O)C4C(=CC=CC=4)N(CCCCC)C3=O)=CC=2OC1.[O:30]1[C:34]2[CH:35]=[CH:36][C:37]([C:39]3([CH2:54][CH2:55][C:56]([O:58]C)=[O:57])[C:47]4[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=4)[N:41]([CH2:48][CH2:49][CH2:50][CH2:51][CH3:52])[C:40]3=[O:53])=[CH:38][C:33]=2[O:32][CH2:31]1>>[O:30]1[C:34]2[CH:35]=[CH:36][C:37]([C:39]3([CH2:54][CH2:55][C:56]([OH:58])=[O:57])[C:47]4[C:42](=[CH:43][CH:44]=[CH:45][CH:46]=4)[N:41]([CH2:48][CH2:49][CH2:50][CH2:51][CH3:52])[C:40]3=[O:53])=[CH:38][C:33]=2[O:32][CH2:31]1Komponenten
3
Versuchsvorschrift
Following the procedure as described in PREPARATION 11E, and making non-critical variations to replace methyl [3-(1,3-benzodioxol-5-yl)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-3-yl]acetate with methyl 3-[3-(1,3-benzodioxol-5-yl)-2-oxo-1-pentyl-2,3-dihydro-1H-indol-3-yl]propanoate, the title compound was obtained (92%) as a colorless solid: MS (ES−) m/z 394.2 (M−1).
Quellen und Nachweise
- ORD-Eintrag
- ord-9b7c0a24b16147ce8fc5534d40b01c41
- Quelldatensatz
- uspto-grants-2013_06