tert-Butyl carbazate → 5-Methyl-2-furohydrazide

HRID 1259872

Reaktionsgleichung

Reaktionsgleichung von HRID 1259872
C(OC(C)(C)C)(=O)[NH:2][NH2:3].[CH3:10][C:11]1[O:15][C:14]([C:16](Cl)=[O:17])=[CH:13][CH:12]=1>C(Cl)Cl>[CH3:10][C:11]1[O:15][C:14]([C:16]([NH:2][NH2:3])=[O:17])=[CH:13][CH:12]=1

Komponenten

4

Edukt 2

HCID 70091tert-Butyl carbazateHCID 27598515-Methylfuran-2-carbonyl chloride

Produkt 1

HCID 41592505-Methyl-2-furohydrazide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

Tert-butyl carbazate (549 mg, 4.15 mmol) was added to a methylene chloride (10 mL) solution of commercially available 5-methylfuran-2-carbonyl chloride (500 mg, 3.46 mmol) under ice cooling, and the mixture was stirred at room temperature for 1 hour. The reaction solution was concentrated, and then, the residue was dissolved in methylene chloride (10 mL). To the solution, trifluoroacetic acid (2 mL) was added, and the mixture was stirred at room temperature for 1.5 hours. The reaction solution was concentrated to obtain 5-methylfuran-2-carbohydrazide.

Aufarbeitung

  1. concentrationThe reaction solution was concentrated
  2. dissolutionthe residue was dissolved in methylene chloride (10 mL)
  3. additionTo the solution, trifluoroacetic acid (2 mL) was added
  4. stirringthe mixture was stirred at room temperature for 1.5 hours
  5. concentrationThe reaction solution was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-694b64273cac4806be76eab314deb09a
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08466290B2

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