Trifluoroacetic acid → HCID 60205213, Verbindung

HRID 1260271Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1260271
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([NH:20][S:21]([C:24]3[CH:29]=[CH:28][C:27]([O:30][C:31]([F:34])([F:33])[F:32])=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH:15]=2)[CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>ClCCl>[NH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([C:14]2[CH:15]=[C:16]([NH:20][S:21]([C:24]3[CH:29]=[CH:28][C:27]([O:30][C:31]([F:34])([F:32])[F:33])=[CH:26][CH:25]=3)(=[O:23])=[O:22])[CH:17]=[CH:18][CH:19]=2)[CH2:9]1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 53628730HCID 53628730, Verbindung

Produkt 1

HCID 60205213HCID 60205213, VerbindungAusbeute 95 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

3-[3-(4-Trifluoromethoxy-benzenesulfonylamino)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester (340 mg, 0.66 mmol) was dissolved in dichloromethane (30 ml). Trifluoroacetic acid (2 ml) was added and the reaction mixture was stirred at room temperature for 1 hour. The reaction mixture was evaporated to dryness. Aqueous NaHCO3 solution (10 ml) was added and extracted twice with ethyl acetate (25 ml). The combined organic phases were dried over magnesium sulfate, filtered, and evaporated to dryness to yield the pure product (250 mg, 95% yield).

Aufarbeitung

  1. customThe reaction mixture was evaporated to dryness
  2. additionAqueous NaHCO3 solution (10 ml) was added
  3. extractionextracted twice with ethyl acetate (25 ml)
  4. dry with materialThe combined organic phases were dried over magnesium sulfate
  5. filtrationfiltered
  6. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-0858bffff47b41a0b130c924adad72db
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470810B2

Notizen zur Reaktion

Wird geladen…