Hydrazine → tert-Butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

HRID 1260286Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1260286
C[C:2]1([C:14]([O-:16])=O)[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1.[NH2:17][NH2:18]>C(O)C>[NH:17]([C:14]([CH:2]1[CH2:6][CH2:5][N:4]([C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8])[CH2:3]1)=[O:16])[NH2:18]

Komponenten

4

Edukt 2

HCID 9321HydrazineHCID 713021051-Tert-butyl 3-methylpyrrolidine-1,3-dicarboxylate

Produkt 1

HCID 4621605tert-Butyl 3-(hydrazinecarbonyl)pyrrolidine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 1-tert-butyl 3-methylpyrrolidine-1,3-dicarboxylate (1.00 equiv.) and hydrazine (excess of 50% aq. solution) in ethanol (0.2 M final conc.) is heated to reflux. After the reaction is deemed complete, the reaction mixture is cooled to rt and partially concentrated. The resulting mixture is diluted with EtOAc, and the resulting organics are washed with water and brine, dried (sodium sulfate) and concentrated in vacuo to afford the title compound i-12a.

Aufarbeitung

  1. concentrationpartially concentrated
  2. additionThe resulting mixture is diluted with EtOAc
  3. washthe resulting organics are washed with water and brine
  4. dry with materialdried (sodium sulfate)
  5. concentrationconcentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-475c15a422bb48de9c3a67e81c75ad45
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470819B2

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