Ethyl Acetate → 5-Chloro-1-(3-fluoro-5-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromide

HRID 1260880Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1260880
[NH2:1][C:2]1[N:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Br:12][CH2:13][C:14]1[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([F:21])[CH:15]=1.C(OCC)(=O)C>CN(C=O)C>[BrH:12].[Cl:11][C:8]1[CH:7]=[C:3]([C:4]([NH2:6])=[O:5])[C:2](=[NH:1])[N:10]([CH2:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([F:21])[CH:15]=2)[CH:9]=1

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 27784513-Fluoro-5-methylbenzyl bromideHCID 668768832-Amino-5-chloronicotinamide

Produkt 1

HCID 686616225-Chloro-1-(3-fluoro-5-methylbenzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrobromideAusbeute 42,4 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A solution of 2-amino-5-chloronicotinamide (150 mg) and 1-(bromomethyl)-3-fluoro-5-methylbenzene (270 mg) in DMF (3 ml) was stirred at 100° C. for 24 hr. After cooling to room temperature, ethyl acetate was added, and the precipitated crystals were filtered and recrystallized to give the title compound (139 mg).

Aufarbeitung

  1. filtrationthe precipitated crystals were filtered
  2. customrecrystallized

Quellen und Nachweise

ORD-Eintrag
ord-eee8f1bdd6fe409ba3a510730a761f4d
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470859B2

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