Cyclopropylboronic acid → HCID 68932049, Verbindung

HRID 1260947Notizen

Reaktionsgleichung

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([N:18]([CH3:29])[C:19](=[O:28])[C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C@H:14]([C:30]3[CH:35]=[CH:34][C:33](Br)=[CH:32][CH:31]=3)[CH2:13]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[CH:37]1(B(O)O)[CH2:39][CH2:38]1>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([C:10]([N:12]2[CH2:17][CH2:16][C@@H:15]([N:18]([CH3:29])[C:19](=[O:28])[C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[C@H:14]([C:30]3[CH:35]=[CH:34][C:33]([CH:37]4[CH2:39][CH2:38]4)=[CH:32][CH:31]=3)[CH2:13]2)=[O:11])[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Komponenten

Edukt 2

HCID 2760897Cyclopropylboronic acid

HCID 68935939HCID 68935939, Verbindung

Produkt 1

HCID 68932049HCID 68932049, Verbindung

Versuchsvorschrift

Using the compound obtained in Example 239 and cyclopropylboronic acid (0.066 g), and by the reaction and purification in the same manner as in Example 242, the title compound was obtained.

Aufarbeitung

customby the reaction and purification in the same manner as in Example 242

Quellen und Nachweise

ORD-Eintrag: ord-90c36bd074f34084b3c7ee0eeef2bf51
Quelldatensatz: uspto-grants-2013_06
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US08470816B2

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