1-Glycoloylpiperidine-4-carboxylic acid → 5-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(hydroxyacetyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylpyridine-2-carboxamide

HRID 1260989Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1260989
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:10]([C@@H:12]2[CH2:17][CH2:16][NH:15][CH2:14][C@H:13]2[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=2)[CH3:11])=[O:9])=[N:6][CH:7]=1.[OH:26][CH2:27][C:28]([N:30]1[CH2:35][CH2:34][CH:33]([C:36](O)=[O:37])[CH2:32][CH2:31]1)=[O:29]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]([N:10]([C@@H:12]2[CH2:17][CH2:16][N:15]([C:36]([CH:33]3[CH2:34][CH2:35][N:30]([C:28](=[O:29])[CH2:27][OH:26])[CH2:31][CH2:32]3)=[O:37])[CH2:14][C@H:13]2[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([Cl:25])[CH:19]=2)[CH3:11])=[O:9])=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 242848391-Glycoloylpiperidine-4-carboxylic acidHCID 866314225-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)piperidin-4-yl]-N-methylpyridine-2-carboxamide

Produkt 1

HCID 689321915-bromo-N-[(3R,4R)-3-(3,4-dichlorophenyl)-1-{[1-(hydroxyacetyl)piperidin-4-yl]carbonyl}piperidin-4-yl]-N-methylpyridine-2-carboxamide

Versuchsvorschrift

Using the compound obtained in step 1 and 1-(hydroxyacetyl)piperidine-4-carboxylic acid, and by the reaction and purification in the same manner as in Example 265, the title compound was obtained.

Aufarbeitung

  1. customby the reaction and purification in the same manner as in Example 265

Quellen und Nachweise

ORD-Eintrag
ord-858049707c254f069489ed1c19886aff
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470816B2

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