1-(Bromomethyl)-4-chlorobenzene → 4-((4-Chlorobenzyl)oxy)-3-fluorobenzaldehyde

HRID 1261078Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1261078
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[F:10][C:11]1[CH:12]=[C:13]([CH:16]=[CH:17][C:18]=1[OH:19])[CH:14]=[O:15]>>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][O:19][C:18]2[CH:17]=[CH:16][C:13]([CH:14]=[O:15])=[CH:12][C:11]=2[F:10])=[CH:4][CH:3]=1

Komponenten

3

Edukt 2

HCID 693291-(Bromomethyl)-4-chlorobenzeneHCID 5872503-Fluoro-4-hydroxybenzaldehyde

Produkt 1

HCID 580863304-((4-Chlorobenzyl)oxy)-3-fluorobenzaldehyde

Versuchsvorschrift

Additional aldehydes were prepared using the protocol of Scheme 62, replacing either 4-chlorobenzyl bromide 557 with a suitable alkylating agent, and/or 3-fluoro-4-hydroxy-benzaldehyde 598 with a suitable aldehyde. The following table indicates the alkylating agent (column 1) and the starting aldehyde (column 2) used to afford the aldehyde (column 3) synthesized following this protocol.

Quellen und Nachweise

ORD-Eintrag
ord-18011494fa284f0d807bc597ae521cc3
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470818B2

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