7-(2-fluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-c]pyridine → 6-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridine

HRID 1261341Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1261341
[Br:1][C:2]1[C:3](Cl)=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1.[F:12][C:13]1[CH:28]=[C:27]([N+:29]([O-:31])=[O:30])[CH:26]=[CH:25][C:14]=1[O:15]C1N=CC=C2C=CNC=12>>[Br:1][C:2]1[C:3]([O:15][C:14]2[CH:25]=[CH:26][C:27]([N+:29]([O-:31])=[O:30])=[CH:28][C:13]=2[F:12])=[C:4]2[S:10][CH:9]=[CH:8][C:5]2=[N:6][CH:7]=1

Komponenten

3

Edukt 2

HCID 594246417-(2-fluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-c]pyridineHCID 594246556-Bromo-7-chlorothieno(3,2-b)pyridine

Produkt 1

HCID 594244576-Bromo-7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridineAusbeute 61 %

Versuchsvorschrift

Starting from the compound 271 and following the procedure described above for the synthesis of compound 260 (scheme 59, example 218, step 2), title compound 272 was obtained in 61% yield as an off-white solid. MS (m/z): 368.9(M+H).

Quellen und Nachweise

ORD-Eintrag
ord-063d8f552dfb45f293f518ec2eace7b5
Quelldatensatz
uspto-grants-2013_06
Patentnummer
US08470850B2

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