Methyl chloroglyoxylate → Methyl (n-(5-chloro-2-propionylphenyl)-N-phenylcarbamoyl)formate

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

A solution of 1-(4-chloro-2-phenylamino-phenyl)-propan-1-one (13.0 g, 50.2 mmol) in toluene (150 mL) at 25° C. was treated with methyl chlorooxoacetate (42.86 g, 350 mmol). The reaction mixture was then heated at 110° C. for 16 h. At this time, the reaction mixture was concentrated in vacuo to afford N-(5-chloro-2-propionyl-phenyl)-N-phenyl-oxalamic acid methyl ester (15.2 g, 87.6%). The material was used without further purification.

Herkunft & Nachweise