5-Amino-2-(trifluoromethyl)benzimidazole → N-tert-Butyl-3-[2-(2-trifluoromethyl-3H-benzimidazol-5-ylamino)-pyrrolo[2,1-f][1,2,4]triazin-7-yl]-benzenesulfonamide

Beteiligte Stoffe

Reaktionsschritte

Following the synthetic and purification procedures described in Example 1293d, N-tert-butyl-3-(2-methanesulfinyl-pyrrolo[2,1-f][1,2,4]triazin-7-yl)-benzenesulfonamide (103 mg, 0.262 mmol) was coupled with 2-trifluoromethyl-3H-benzimidazol-5-ylamine (91 mg, 0.45 mmol) at 105° C. for 132 h to afford the title compound. Yield of TFA salt: 15 mg (26%) of brown powder; LC/MS: 529 (M+H); HPLC: 97% pure, RT=2.16 min; 1H NMR: (DMSO, δ) 9.68 (s, 1H), 9.07 (s, 1H), 8.53 (m, 2H), 8.02 (s, 1H), 7.86 (d, J=8.0, 1H), 7.83 (dd, J=9.1, 1.8, 1H), 7.75 (m, 3H), 7.25 (d, J=4.7, 1H), 7.03 (d, J=4.7, 1H), 1.12 (s, 9H)-benzimidazole NH presumably underwent rapid exchange with residual water.

Herkunft & Nachweise