Ethyl propanimidoate → HCID 178512693, Verbindung

HRID 1262656Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1262656
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10](NN)=[O:11])[N:9]=1)[C:2]([NH2:4])=[NH:3].C(=N)([O:17]CC)CC.Cl.C(=N)(OCC)CC>C(O)C>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([C:10]([OH:11])=[O:17])[N:9]=1)[C:2]([NH2:4])=[NH:3]

Komponenten

5

Edukt 3

HCID 11240515Ethyl propanimidoateHCID 13000588Ethyl propanecarboximidate hydrochlorideHCID 178512692HCID 178512692, Verbindung

Produkt 1

HCID 178512693HCID 178512693, VerbindungAusbeute 103,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2.90 g (14.48 mmol) of 2-guanidino-4-thiazole carboxylic acid hydrazide in 50 ml dry ethanol was slurried with 29.1 mmol of ethyl propionimidate (prepared from 4.0 g (29.1 mmol) of ethyl propionimidate hydrochloride) for 5 days at 25°. The slurry was filtered and the resulting solid was dried for 2 hours at 60° in vacuo to give 2.802 g (75%) of 2-guanidino-4-thiazole carboxylic acid 2-propioniminohydrazide.

Aufarbeitung

  1. filtrationThe slurry was filtered
  2. customthe resulting solid was dried for 2 hours at 60° in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-f097a400a44849ae93b29f5b405250ef
Quelldatensatz
uspto-grants-1984_06
Patentnummer
US04452987

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