Benzylamine → Diethyl 3-benzylamino-2-pentenedioate

HRID 1262955

Reaktionsgleichung

Reaktionsgleichung von HRID 1262955
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][CH2:10][O:11][C:12]([CH2:14][C:15]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])=O)=[O:13]>C1(C)C=CC=CC=1>[CH2:10]([O:11][C:12](=[O:13])[CH:14]=[C:15]([NH:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH3:9]

Komponenten

4

Edukt 2

HCID 7504BenzylamineHCID 66045Diethyl acetonedicarboxylate

Produkt 1

HCID 70353029Diethyl 3-benzylamino-2-pentenedioate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

Benzylamine (89.1 g, 0.83 moles) is added over 10 minutes to a suspension of 5A powdered molecular sieves (270 g) and diethyl 1,3-acetonedicarboxylate (160 g) (0.79 moles) in 350 ml toluene (external cooling applied to control exotherm). The suspension is stirred at room temperature for 14-17 hours and then filtered to provide 2. The filter cake is washed with three portions of toluene. The combined filtrates may be used as in the subsequent ketene reaction.

Aufarbeitung

  1. filtrationfiltered
  2. customto provide 2
  3. washThe filter cake is washed with three portions of toluene
  4. customThe combined filtrates may be used as in the subsequent ketene reaction

Quellen und Nachweise

ORD-Eintrag
ord-3d56d55105f14d65bb30d9b980cfad2f
Quelldatensatz
uspto-grants-1984_06
Patentnummer
US04454332

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