Chlorosuccinimide → 2-Amino-5-chloro-3-nitrobenzamide

HRID 12632Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 12632
[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[Cl:14]N1C(=O)CCC1=O>C(#N)C>[NH2:1][C:2]1[C:10]([N+:11]([O-:13])=[O:12])=[CH:9][C:8]([Cl:14])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 107974762-Amino-3-nitrobenzamide

Produkt 1

HCID 251933202-Amino-5-chloro-3-nitrobenzamideAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6342AcetonitrileLösungsmittel

Versuchsvorschrift

2-Amino-3-nitrobenzamide (4.0 g) in warm anhydrous acetonitrile (1.25 L) was treated with N-chlorosuccinimide (3.1 g) at 60° C. under nitrogen for 20 hours. The mixture was allowed to cool to room temperature and filtered. The filter cake was washed with acetonitrile and dried to provide the title compound (3.98 g, 84%). MS (DCI/NH3) m/z 216 (M+H)+.

Aufarbeitung

  1. filtrationfiltered
  2. washThe filter cake was washed with acetonitrile
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-caab6c8690124ab0a60e8c9035a4719f
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07728026B2

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