HCID 18617480, Verbindung → HCID 18617845, Verbindung

HRID 1264213Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1264213
[O:1]1C=CC=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13]([NH2:15])=[O:14])=[CH:8][CH:7]=1.CC#N.C(Cl)(Cl)(Cl)Cl.[OH2:26]>C(OCC)(=O)C>[C:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:17])([CH3:16])[C:13]([NH2:15])=[O:14])=[CH:8][CH:7]=1)([OH:1])=[O:26]

Komponenten

4

Edukt 2

HCID 18617480HCID 18617480, VerbindungHCID 22592919water acetonitrile CCl4

Produkt 1

HCID 18617845HCID 18617845, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

To a solution of 2-(4-(furan-2-yl)-phenyl)-2-methyl-propionamide (reference example 26) (124 mg, 0.5 mmol) in CH3CN/CCl4/H2O (7 mL, 2/2/3) is added NaIO4 (420 mg, 2 mmol) followed by RuCl3 (H2O)(3 mg). The resulting mixture is stirred vigorously for 1.5 h, then diluted with ethyl acetate, washed with water and brine, dried over MgSO4 and concentrated to give 100 mg of the title compound as an orange solid. 1H NMR (CD3OD) d 1.58 (s, 6H), 7.50 (d, J=8 Hz, 2H), 7.98 (d, J=8 Hz, 2H). MS (EI) m/z 208 (M+H).

Aufarbeitung

  1. washwashed with water and brine
  2. dry with materialdried over MgSO4
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-0de5536d44ec4a26ab90c97a182724fb
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06541505B1

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