Methanol → Methyl 5-chloro-2,3-dihydroxybenzoate

HRID 1264650Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1264650
S(=O)(=O)(O)O.[Cl:6][C:7]1[CH:8]=[C:9]([OH:17])[C:10]([OH:16])=[C:11]([CH:15]=1)[C:12]([OH:14])=[O:13].[CH3:18]O>>[Cl:6][C:7]1[CH:8]=[C:9]([OH:17])[C:10]([OH:16])=[C:11]([CH:15]=1)[C:12]([O:14][CH3:18])=[O:13]

Komponenten

4

Edukt 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 123948825-Chloro-2,3-dihydroxybenzoic acid

Produkt 1

HCID 18613685Methyl 5-chloro-2,3-dihydroxybenzoate

Versuchsvorschrift

A mixture of methanol (60 ml) and sulfuric acid (5.2 ml) was stirred at room temperature. 5-Chloro-2,3-dihydroxybenzoic acid (0.11 mol) was added. The reaction mixture was stirred and refluxed for 20 hours, and then poured out onto ice. The precipitate was filtered off, washed with water, and dried, yielding 18.48 g of methyl 5-chloro-2,3-dihydroxybenzoate (intermediate 9; mp: 102° C.).

Aufarbeitung

  1. stirringThe reaction mixture was stirred
  2. temperaturerefluxed for 20 hours
  3. additionpoured out onto ice
  4. filtrationThe precipitate was filtered off
  5. washwashed with water
  6. customdried

Quellen und Nachweise

ORD-Eintrag
ord-70915e134a844ed1b78dfc4e36e9fbde
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06544997B1

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