4-Pyridinecarbothioamide → Ethyl 4-[2-(4-pyridyl)-4-thiazolyl)benzoate hydrobromide
Reaktionsgleichung
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[Br:10][CH2:11][C:12]([C:14]1[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=1)=O>>[BrH:10].[N:5]1[CH:6]=[CH:7][C:2]([C:1]2[S:8][CH:11]=[C:12]([C:14]3[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=3)[N:9]=2)=[CH:3][CH:4]=1Komponenten
3
Versuchsvorschrift
In the same manner as in Example 74, thioisonicotinamide was reacted with ethyl 4-bromoacetylbenzoate to obtain ethyl 4-[2-(4-pyridyl)-4-thiazolyl)benzoate hydrobromide. The product was, recrystallized from ethanol. Yield: 67%. Pale Yellow prisms. Melting point: 247 to 248° C.
Quellen und Nachweise
- ORD-Eintrag
- ord-2112c5fbc84a471482d1dcee802a2480
- Quelldatensatz
- uspto-grants-2003_04