m-Chloroperbenzoic acid → HCID 9801756, Verbindung

HRID 1265177Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1265177
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([NH:18][C:19](=[O:21])[CH3:20])=[C:16]2[CH2:22][S:23][CH2:24][C:15]2=[N:14]1.C1C=C(Cl)C=C(C(OO)=[O:33])C=1.C([O-])(O)=O.[Na+]>C(Cl)Cl>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:10])([F:11])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[N:13]1[C:17]([NH:18][C:19](=[O:21])[CH3:20])=[C:16]2[CH2:22][S:23](=[O:33])[CH2:24][C:15]2=[N:14]1

Komponenten

5

Edukt 3

HCID 70297m-Chloroperbenzoic acidHCID 516892Sodium BicarbonateHCID 9800860HCID 9800860, Verbindung

Produkt 1

HCID 9801756HCID 9801756, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of acetamide (2) (145 mg, 0.37 mmol) in CH2Cl2 (5 mL), m-CPBA (500 mg) was added. The reaction mixture was stirred at room temperature for 30 min. and aq. NaHCO3 (10 mL) was added and the organic layer separated and washed with water (2×10 mL), dried (Na2SO4) and concentrated to obtain the title compound as a white solid. (35%); 1H NMR (CDCl3) δ 7.8 (2H, m), 4.33 and 4.46 (2H each, m), 2.12 (3H, s); MS (M+) 428.

Aufarbeitung

  1. customthe organic layer separated
  2. washwashed with water (2×10 mL)
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-1616ba520a78403baf217fd516e62d45
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06545033B1

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