Nitric Acid → 2-(4-Chloro-6-fluoro-3-hydroxy-2-nitrophenyl)-5-trifluoromethylpyridazin-3-one
Reaktionsgleichung
[N+:1]([O-:4])(O)=[O:2].[Cl:5][C:6]1[C:11]([OH:12])=[CH:10][C:9]([N:13]2[C:18](=[O:19])[CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=[N:14]2)=[C:8]([F:24])[CH:7]=1>>[Cl:5][C:6]1[CH:7]=[C:8]([F:24])[C:9]([N:13]2[C:18](=[O:19])[CH:17]=[C:16]([C:20]([F:21])([F:22])[F:23])[CH:15]=[N:14]2)=[C:10]([N+:1]([O-:4])=[O:2])[C:11]=1[OH:12]Komponenten
3
Versuchsvorschrift
Nitric acid (70%, 12 ml) was added to the ice-cooled 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-5-trifluoromethylpyridazin-3-one (1.25 g) and stirred at room temperature for 30 minutes. Crushed ice was added. The precipitate was collected by filtration and washed with water to give 1.20 g of the desired product, m.p. 146-8° C.
Aufarbeitung
- additionCrushed ice was added
- filtrationThe precipitate was collected by filtration
- wash