HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Aldoxime → 3-[3-(3-Methyl-isoxazol-5-yl)-phenyl)-3-oxo-propionic acid tert-butyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Aldoxime | HCID 7863 | — |
| Edukt | Chlorosuccinimide | HCID 31398 | — |
| Edukt | Ethyl 3-ethynylbenzoate | HCID 15540684 | — |
| Edukt | Ethyl 3-(3-methyl-isoxazol-5-yl)-benzoate | HCID 22224947 | — |
| Edukt | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| Lösungsmittel | Pyridine | HCID 1049 | — |
| Lösungsmittel | Chloroform | HCID 6212 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 3-[3-(3-Methyl-isoxazol-5-yl)-phenyl)-3-oxo-propionic acid tert-butyl ester | HCID 69592871 | — |
Reaktionsschritte
The title compound was prepared from ethyl 3-(3-methyl-isoxazol-5-yl)-benzoate [prepared by reaction of ethyl 3-ethynylbenzoate [CAS-No. 178742-95-5] with a mixture of NCS, acetaldoxime, Et3N and cat. amount of pyridine in CHCl3 at 50° C. according to Tetrahedron 1984, 40, 2985-2988] by treatment with lithium tert.-butyl acetate according to general procedure K (method b). Obtained as a yellow solid (2.54 g).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06544985B2 |
| Quelldatensatz | uspto-grants-2003_04 |
| ORD ID | ord-c2e8776cd85a4969b8ba41fd7f244956 |
| Quellennotiz | uspto-grants-2003_04 |