Acetamide → 3-(2-Methyl-oxazol-4-yl)-benzoic acid
Reaktionsgleichung
Br[CH2:2][C:3]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])=O.[C:14]([NH2:17])(=[O:16])[CH3:15]>>[CH3:15][C:14]1[O:16][CH:2]=[C:3]([C:5]2[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=2)[C:8]([OH:10])=[O:9])[N:17]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 130 °C
Versuchsvorschrift
A mixture of 3-(2-bromo-acetyl)-benzoic acid (2.43 g) and acetamide (1.77 g) was heated with stirring to 130° C. for 40 min. The mixture was cooled and diluted with H2(30 mL) and the precipitate formed was collected by filtration to give 3-(2-methyl-oxazol-4-yl)-benzoic acid (1.51 g) as brown solid.
Aufarbeitung
- temperaturewas heated
- temperatureThe mixture was cooled
- additiondiluted with H2(30 mL)
- customthe precipitate formed
- filtrationwas collected by filtration
Quellen und Nachweise
- ORD-Eintrag
- ord-1fbba387afe0432ea075cd882750885f
- Quelldatensatz
- uspto-grants-2003_04
- Patentnummer
- US06544985B2
Notizen zur Reaktion
Wird geladen…