HCID 69689153, Verbindung → HCID 69688856, Verbindung
Reaktionsgleichung
CO[C:3](=[O:24])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[S:11][C:12]([CH2:15][CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)=[N:13][N:14]=2)[CH:5]=1.[C:25]([O:28][C:29]([CH3:32])([CH3:31])[CH3:30])(=[O:27])[CH3:26].[Li]>>[C:29]([O:28][C:25](=[O:27])[CH2:26][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[S:11][C:12]([CH2:15][CH2:16][O:17][CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][O:19]3)=[N:13][N:14]=2)[CH:5]=1)([CH3:32])([CH3:31])[CH3:30]Komponenten
3
Versuchsvorschrift
3-(5-[2-(Tetrahydro-pyran-2-yloxy)-ethyl]-[1,3,4]thiadiazol-2-yl}-benzoic acid methyl ester (1.60 g) was treated with lithium tert.-butyl acetate according to general procedure K (method b) to give 3-oxo-3-(3-{5-[2-(tetrahydro-pyran-2-yloxy)-ethyl]-[1,3,4]thiadiazol-2-yl}-phenyl)-propionic acid tert-butyl ester (2.1 g) as a pale-yellow oil.
Quellen und Nachweise
- ORD-Eintrag
- ord-d8e4218d1f9c4610a4a5bca2df48c295
- Quelldatensatz
- uspto-grants-2003_04