Formamide → Methyl 3-[5-methyl-oxazol-4-yl]-benzoate
Reaktionsgleichung
[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10](=O)[CH:11](Br)[CH3:12])[CH:5]=1.[CH:16]([NH2:18])=[O:17]>>[CH3:1][O:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:18]=[CH:16][O:17][C:11]=2[CH3:12])[CH:5]=1Komponenten
3
Versuchsvorschrift
rac-3-(2-Bromo-propionyl)-benzoic acid methyl ester (5.42 g) and formamide (3.6 ml) were heated together to 130° C. for 5 h. The mixture was partitioned between AcOEt and brine, the organic layer was dried and evaporated and the residual oil was chromatographed on silica gel using AcOEt/hexane (1:4) as eluent to give 3-(5-methyl-oxazol-4-yl)-benzoic acid methyl ester (2.52 g) as white solid.
Aufarbeitung
- customThe mixture was partitioned between AcOEt and brine
- customthe organic layer was dried
- customevaporated
- customthe residual oil was chromatographed on silica gel