alpha-Chloro-m-nitrotoluene → 1-Methyl-4-(3-nitrobenzyl)piperazine

HRID 1266211Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1266211
[N+:1]([C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][CH:11]=1)[CH2:7]Cl)([O-:3])=[O:2].[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>>[CH3:12][N:13]1[CH2:18][CH2:17][N:16]([CH2:7][C:6]2[CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:11]=[CH:10][CH:9]=2)[CH2:15][CH2:14]1

Komponenten

3

Edukt 2

HCID 12078alpha-Chloro-m-nitrotolueneHCID 531671-Methylpiperazine

Produkt 1

HCID 13771091-Methyl-4-(3-nitrobenzyl)piperazine

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 3-nitrobenzyl chloride (1 g) and N-methylpiperazine (3 ml) was stirred and heated to 100° C. for 4 hours. The mixture was cooled to ambient temperature and partitioned between methylene chloride and water. The organic phase was evaporated to give 3-(4-methylpiperazin-1-ylmethyl)nitrobenzene (1.05 g); NMR Spectrum: (DMSOd6) 2.14 (s, 3H), 2.31-2.38 (m, 8H), 3.57 (s, 2H), 7.6 (t, 1H), 7.54 (d, 1H), 8.07-8.13 (m, 2H).

Aufarbeitung

  1. temperatureThe mixture was cooled to ambient temperature
  2. custompartitioned between methylene chloride and water
  3. customThe organic phase was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-15704b4784cc4f2ab644fad7b20edfdc
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06548514B1

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