Hydrochloric Acid → 1-(3-Hydroxypropyl)-5-(3-methylthiophen-2-yl)pyrimidine-2,4(1H,3H)-dione

HRID 12663Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 12663
C([Si](C)(C)[O:6][CH2:7][CH2:8][CH2:9][N:10]1[CH:15]=[C:14]([C:16]2[S:17][CH:18]=[CH:19][C:20]=2[CH3:21])[C:13](=[O:22])[NH:12][C:11]1=[O:23])(C)(C)C.Cl>O1CCOCC1>[OH:6][CH2:7][CH2:8][CH2:9][N:10]1[CH:15]=[C:14]([C:16]2[S:17][CH:18]=[CH:19][C:20]=2[CH3:21])[C:13](=[O:22])[NH:12][C:11]1=[O:23]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 686913001-[3-(tert-Butyl-dimethyl-silanyloxy)-propyl]-5-(3-methyl-thiophen-2-yl)-1H-pyrimidine-2,4-dione

Produkt 1

HCID 589941881-(3-Hydroxypropyl)-5-(3-methylthiophen-2-yl)pyrimidine-2,4(1H,3H)-dioneAusbeute 72 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

A solution of 1-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-5-(3-methyl-thiophen-2-yl)-1H-pyrimidine-2,4-dione (Prep 27, 73 mg, 0.2 mmol) in dioxane (8 mL) was cooled at 0° C. and then 4N HCl in dioxane (0.5 mL) was added. The mixture was stirred for 1 hour at room temperature and then the solvent was evaporated. The crude was purified by trituration with diisopropylether to afford the title compound as a white solid (36 mg, 72% yield).

Aufarbeitung

  1. customthe solvent was evaporated
  2. customThe crude was purified by trituration with diisopropylether

Quellen und Nachweise

ORD-Eintrag
ord-61cb07fdf24b499da184216c1f1a6b39
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07727988B2

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